Cologuard Plus™.

Introducing Cologuard PlusTM

Greater accuracy, same ease of use.

Screen with the leading noninvasive colon cancer test in the privacy of your home1

  • FDA approved
  • No prep, no time off
  • Collect a sample in a few minutes2
  • Most people pay $0*
Two boxes of Cologuard on top of each other.

WHY EARLY DETECTION IS IMPORTANT

There’s no such thing as low risk for colon cancer

3rd

most common cancer among
men and women.3

75%

of people with colon cancer
have no family history.4

51%

increase of colon cancer rates in
adults under 50 since 1994.5

The Cologuard mascot standing with his hands on his hips.

HOW MUCH DOES COLOGUARD® TEST COST?

Most patients pay $0*

96% of users pay nothing with insurance. Cologuard is covered by Medicare, most major plans, and an eligible expense for flexible spending accounts (HSA, HRA, FSA).

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WHY THE COLOGUARD TEST

The leading noninvasive solution1

Made for individuals 45+ at average risk, the Cologuard test stands out for its ease of use and proven effectiveness. Collect a sample in a few minutes.2

A chart that shows how Cologuard compares  with a colonoscopy plus FIT, FOBT, and blood tests.

Any noninvasive test with a positive result will need a follow-up colonoscopy.

§FOBT requires changes to diet or medication5

§§Mobile phlebotomy may be available to collect a blood-based test sample at home with assistance from a medical professional10

Indicated for the detection of fecal occult blood6

#Current FDA-approved CRC blood test not indicated for precancer detection9

THE STORY BEHIND THE TEST

Backed by science, powered by technology11,12

Cologuard finds colon cancer even in its early stages when it is more treatable.3

A microcospic image of cells.

Gathering cells to uncover your body’s natural clues

  • Polyps are small, usually harmless growths in the colon
  • Left undetected, they can develop into cancer over time
  • These polyps can shed cells or leave behind microscopic amounts of blood in the stool that become clues to detecting cancer
Illustration of a DNA strand.

Advanced technology for targeted analysis

  • Using exclusive technology, your stool sample goes through a purification process in our lab
  • Cologuard uses a precise biomarker panel to detect 10 distinct DNA markers (signs of DNA damage) and tiny blood traces, focusing on key mutations linked to colon cancer
  • This multi-marker approach can detect cancer early, even before symptoms appear or become serious
Illustration of a biomarker test panel with a syringe releasing a blood specimen.

Clear and actionable results within 2 weeks

  • Abnormal DNA or blood findings are weighted for a more accurate prediction of your risk for colon cancer
  • A positive result may mean a higher-than-average risk of precancerous polyps or colon cancer, while a negative result suggests a lower-than-average risk

AN FDA-APPROVED CHOICE

Trusted by over 340,000 providers.13 Chosen by 20 million patients.14

  • A pair of hands about to open a Cologuard box.

    Meghan_Patient_Story

  • A smiling woman wearing sunglasses.
    Test Title

A doctor holding a Cologuard box.

BACKED BY EXPERTS

“I believe timely screening will help save lives, and early detection with the Cologuard test can help.”

Belinda Khou, PA

Belinda Khou has been compensated for sharing her expertise and for acting as a consultant for Exact Sciences.

HOW TO GET THE COLOGUARD TEST

Two easy ways, one smart choice

A man and a woman look at a laptop while talking to each other.

Request online

Answer a few questions, and one of our telehealth providers can prescribe Cologuard for you.

A doctor holding a chart is talking to his patient.

Talk with your provider

Your health care provider can prescribe Cologuard at any time. Our discussion guide makes starting those conversations easy.

If you’ve discussed Cologuard with your health care provider in the past and believe it may have been ordered for you, please call Exact Sciences Laboratories at 1-844-870-8870.

Telehealth may be offered by your health care provider.

Telehealth providers may charge a fee for their services associated with the consultation. Telehealth providers operate independently from Exact Sciences and Exact Sciences Laboratories. Only orders from licensed health care providers are accepted.

You’ve got questions,
we’ve got answers

Cologuard is an FDA-approved, noninvasive, prescription-based, use-at-home collection kit for screening people 45 or older who are at average risk for colon cancer. Use it in the privacy of your home and ship it back to our lab for testing.

Cologuard is for adults 45 years of age and older who are at average risk for colon cancer. It is not a replacement for colonoscopy in high-risk individuals.

Cologuard uses advanced stool technology to detect DNA and blood cells released from altered cells. It can detect both precancer and cancer.

Cologuard found 92% of all colon cancers (and 94% of all stage I & II cancers) in a clinical study of 10,000 participants, ages 50-84 years old, who are of average risk for colorectal cancer.
  • Imperiale TF, Ransohoff DF, Itzkowitz SH, et al. Multitarget stool DNA testing for colorectal-cancer screening. N Engl J Med. 2014;370(14):1287-1297.

If you’re 45+ and at average risk for colon cancer, there are two easy ways to request Cologuard: online or through your health care provider. Either way, we’ll deliver your prescribed kit right to your door.

Cologuard Plus is the latest advancement in Cologuard® testing. Like the current test, Cologuard Plus is FDA approved.

You can request Cologuard Plus through your health care provider. Your insurance coverage will determine which version of the test you should receive. You can also request your test by ordering with self-pay.